[HTML][HTML] Evidence for multiple complementary pathways for efficient cholesterol absorption in mice

J Iqbal, MM Hussain - Journal of lipid research, 2005 - ASBMB
Apolipoprotein B (apoB)-dependent and apoB-independent pathways for cholesterol
transport have been described in cultured cells. Here, we show that the apoB-independent
pathway involves apoA-I-containing high density lipoproteins (HDLs). Cholesterol secretion
by the HDLs, but not by the apoB pathway, was significantly reduced in primary enterocytes
isolated from chow-and cholesterol-fed apoA-I−/− mice. These enterocytes were capable of
cholesterol efflux when apoA-I was provided extracellularly. In apoA-I−/− mice, the …