[HTML][HTML] Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2
In this study, we tested the hypothesis that two separate pathways, the two-step process and
an apolipoprotein B (apoB) size-dependent lipidation process, give rise to different
lipoproteins. Expression of apoB-100 and C-terminally truncated forms of apoB-100 in McA-
RH7777 cells demonstrated that VLDL particles can be assembled by apoB size-dependent
linear lipidation, resulting in particles whose density is inversely related to the size of apoB.
This lipidation results in a LDL-VLDL 2 particle containing apoB-100. VLDL 1 is assembled …
an apolipoprotein B (apoB) size-dependent lipidation process, give rise to different
lipoproteins. Expression of apoB-100 and C-terminally truncated forms of apoB-100 in McA-
RH7777 cells demonstrated that VLDL particles can be assembled by apoB size-dependent
linear lipidation, resulting in particles whose density is inversely related to the size of apoB.
This lipidation results in a LDL-VLDL 2 particle containing apoB-100. VLDL 1 is assembled …