[HTML][HTML] Identification of the proteoglycan binding site in apolipoprotein B48
C Flood, M Gustafsson, PE Richardson… - Journal of Biological …, 2002 - ASBMB
An initial event in atherosclerosis is the retention of lipoproteins within the intima of the
vessel wall. Previously we identified Site B (residues 3359–3369) in apolipoprotein (apo)
B100 as the proteoglycan binding sequence in low density lipoproteins (LDLs) and showed
that the atherogenicity of apoB-containing lipoproteins is linked to their affinity for artery wall
proteoglycans. However, both apoB100-and apoB48-containing lipoproteins are equally
atherogenic even though Site B lies in the carboxyl-terminal half of apoB100 and is absent …
vessel wall. Previously we identified Site B (residues 3359–3369) in apolipoprotein (apo)
B100 as the proteoglycan binding sequence in low density lipoproteins (LDLs) and showed
that the atherogenicity of apoB-containing lipoproteins is linked to their affinity for artery wall
proteoglycans. However, both apoB100-and apoB48-containing lipoproteins are equally
atherogenic even though Site B lies in the carboxyl-terminal half of apoB100 and is absent …