[HTML][HTML] Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo
M Van Eck, M Hoekstra, R Out, IST Bos, JK Kruijt… - Journal of lipid …, 2008 - ASBMB
Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the
selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL
metabolism, however, is largely unknown. SR-BI deficiency resulted in elevated VLDL
cholesterol levels, both on chow diet and upon challenge with high-cholesterol diets. To
specifically elucidate the role of SR-BI in VLDL metabolism, the plasma clearance and
hepatic uptake of 125 I-β-VLDL were studied in SR-BI+/+ and SR-BI−/− mice. At 20 min after …
selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL
metabolism, however, is largely unknown. SR-BI deficiency resulted in elevated VLDL
cholesterol levels, both on chow diet and upon challenge with high-cholesterol diets. To
specifically elucidate the role of SR-BI in VLDL metabolism, the plasma clearance and
hepatic uptake of 125 I-β-VLDL were studied in SR-BI+/+ and SR-BI−/− mice. At 20 min after …