Tissue factor in neutrophils: yes
S Nakamura, T Imamura, K Okamoto - Journal of Thrombosis and …, 2004 - jthjournal.org
Tissue factor (TF, CD142 [1]) initiates blood clotting through interaction with factor (F)
VII/VIIa. TF is also known to participate in signal transduction, angiogenesis, embryogenesis,
or tumor metastasis [2±6]. Among the leukocytes, only monocytes have been reported to
express TF, but others, neutrophils (polymorphonuclear leukocytes) or lymphocytes, have
not. Neutrophilic leukocytes have been proposed to produce TF [7, 8], though there was little
direct evidence to elucidate TF expression/production in these leukocytes. Recently we …
VII/VIIa. TF is also known to participate in signal transduction, angiogenesis, embryogenesis,
or tumor metastasis [2±6]. Among the leukocytes, only monocytes have been reported to
express TF, but others, neutrophils (polymorphonuclear leukocytes) or lymphocytes, have
not. Neutrophilic leukocytes have been proposed to produce TF [7, 8], though there was little
direct evidence to elucidate TF expression/production in these leukocytes. Recently we …