Introduction 3. Platelets and endothelium are the source of proteins for coagulation and inflammation 3.1. Endothelial cell adhesion molecules

3.2. Pletelet glycoproteins for cell adhesion, aggreration and inflammation 4. Tissue factor as trigger of blood coagulation 4.1. TF structure and functions 4.2. Generation of hemostatic serine proteinases 4.3. Regulation of blood coagulation and inflammation by TFPI 5. Functions of hemostatic serine proteinases in inflammation 5.1. Thrombin signalling pathways in inflammation 5.2. TF/FVIIa/Xa-induced inflammation 5.3. Termination of PAR signaling. 6. Control of inflammation by natural anticoagulant pathways 6.1. Antiinflammatory properties of protein C system 6.2. Endothelial protein C receptor as regulator of coagulation and inflammation. 6.3. Antiinflammatory properties of antithrombin 7. The new approach to correction of TF/VIIa/Xa-dependented thrombosis and conjugated prosseses 8. Summary and perspective