[HTML][HTML] CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface
L Wilkinson, G Kolle, D Wen, M Piper, J Scott… - Journal of Biological …, 2003 - ASBMB
The Crim1 gene is predicted to encode a transmembrane protein containing six von
Willebrand-like cysteine-rich repeats (CRRs) similar to those in the BMP-binding antagonist
Chordin (Chrd). In this study, we verify that CRIM1 is a glycosylated, Type I transmembrane
protein and demonstrate that the extracellular CRR-containing domain can also be secreted,
presumably via processing at the membrane. We have previously demonstrated Crim1
expression at sites consistent with an interaction with bone morphogenetic proteins (BMPs) …
Willebrand-like cysteine-rich repeats (CRRs) similar to those in the BMP-binding antagonist
Chordin (Chrd). In this study, we verify that CRIM1 is a glycosylated, Type I transmembrane
protein and demonstrate that the extracellular CRR-containing domain can also be secreted,
presumably via processing at the membrane. We have previously demonstrated Crim1
expression at sites consistent with an interaction with bone morphogenetic proteins (BMPs) …