[HTML][HTML] The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver …
N Kinnman, C Francoz, V Barbu, D Wendum… - Laboratory …, 2003 - Elsevier
The origin of myofibroblasts and the factors promoting their differentiation during liver
fibrogenesis remain uncertain. During biliary-type fibrogenesis, the proliferation and
chemoattraction of hepatic stellate cells (HSC) toward bile ducts is mediated by platelet-
derived growth factor (PDGF), while myofibroblastic conversion of peribiliary cells distinct
from HSC also occurs. We herein examined the phenotype of these peribiliary
myofibroblasts as compared with myofibroblastic HSC and tested whether their …
fibrogenesis remain uncertain. During biliary-type fibrogenesis, the proliferation and
chemoattraction of hepatic stellate cells (HSC) toward bile ducts is mediated by platelet-
derived growth factor (PDGF), while myofibroblastic conversion of peribiliary cells distinct
from HSC also occurs. We herein examined the phenotype of these peribiliary
myofibroblasts as compared with myofibroblastic HSC and tested whether their …