[HTML][HTML] CCN2 is necessary for adhesive responses to transforming growth factor-β1 in embryonic fibroblasts
X Shi-wen, LA Stanton, L Kennedy, D Pala… - Journal of Biological …, 2006 - ASBMB
CCN2 is induced by transforming growth factor-β (TGFβ) in fibroblasts and is overexpressed
in connective tissue disease. CCN2 has been proposed to be a downstream mediator of
TGFβ action in fibroblasts; however, the role of CCN2 in regulating this process unclear. By
using embryonic fibroblasts isolated from ccn2–/–mice, we showed that CCN2 is required for
a subset of responses to TGFβ. Affymetrix genome-wide expression profiling revealed that
942 transcripts were induced by TGFβ greater than 2-fold in ccn2+/+ fibroblasts, of which …
in connective tissue disease. CCN2 has been proposed to be a downstream mediator of
TGFβ action in fibroblasts; however, the role of CCN2 in regulating this process unclear. By
using embryonic fibroblasts isolated from ccn2–/–mice, we showed that CCN2 is required for
a subset of responses to TGFβ. Affymetrix genome-wide expression profiling revealed that
942 transcripts were induced by TGFβ greater than 2-fold in ccn2+/+ fibroblasts, of which …