CD4+ CD25+ FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis
Multiple sclerosis (MS) is an autoimmune disorder directed against self antigens of the
central nervous system. CD4+ CD25+ FoxP3+ regulatory T cell (Treg) mediated suppression
is an essential mechanism of self-tolerance. We studied whether changes in the suppressive
function of a mixture of CD25high and CD25intemediate expressing Treg cells in myelin
basic protein (MBP)-induced proliferation occurred in untreated MS patients. Suppression of
MBP-induced proliferation was observed in 13 out of 29 (45%) MS patients; this was …
central nervous system. CD4+ CD25+ FoxP3+ regulatory T cell (Treg) mediated suppression
is an essential mechanism of self-tolerance. We studied whether changes in the suppressive
function of a mixture of CD25high and CD25intemediate expressing Treg cells in myelin
basic protein (MBP)-induced proliferation occurred in untreated MS patients. Suppression of
MBP-induced proliferation was observed in 13 out of 29 (45%) MS patients; this was …