Endothelial cell–cell junctions: happy together
E Dejana - Nature reviews Molecular cell biology, 2004 - nature.com
Nature reviews Molecular cell biology, 2004•nature.com
Junctional structures maintain the integrity of the endothelium. Recent studies have shown
that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals
that regulate contact-induced inhibition of cell growth, apoptosis, gene expression and new
vessel formation. Moreover, modifications of the molecular organization and intracellular
signalling of junctional proteins might have complex effects on vascular homeostasis.
that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals
that regulate contact-induced inhibition of cell growth, apoptosis, gene expression and new
vessel formation. Moreover, modifications of the molecular organization and intracellular
signalling of junctional proteins might have complex effects on vascular homeostasis.
Abstract
Junctional structures maintain the integrity of the endothelium. Recent studies have shown that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals that regulate contact-induced inhibition of cell growth, apoptosis, gene expression and new vessel formation. Moreover, modifications of the molecular organization and intracellular signalling of junctional proteins might have complex effects on vascular homeostasis.
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