[HTML][HTML] Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain
KL Bennett, J Bradshaw, T Youngman… - Journal of Biological …, 1997 - ASBMB
DCC (deleted incolorectal carcinoma) is a broadly expressed cell-surface receptor. Netrin-1
was recently identified as a DCC ligand in brain, but the possibility of other DCC ligands was
suggested by the finding that an anti-DCC antibody (clone AF5) neutralized netrin-1-
dependent commissural axon outgrowth without blocking DCC/netrin-1 interactions. Here
we have searched for alternative cell-surface DCC ligands. A DCC-Ig fusion protein bound
to neural and epithelial derived cell lines, indicating that these lines express ligand (s) for …
was recently identified as a DCC ligand in brain, but the possibility of other DCC ligands was
suggested by the finding that an anti-DCC antibody (clone AF5) neutralized netrin-1-
dependent commissural axon outgrowth without blocking DCC/netrin-1 interactions. Here
we have searched for alternative cell-surface DCC ligands. A DCC-Ig fusion protein bound
to neural and epithelial derived cell lines, indicating that these lines express ligand (s) for …