Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface
HK Eltzschig, CF MacManus, SP Colgan - Trends in cardiovascular …, 2008 - Elsevier
Nucleotide signaling is currently an area of intense investigation. Extracellular adenosine
triphosphate (ATP) liberated during hypoxia or inflammation can either signal directly to
purinergic receptors or, after phosphohydrolytic metabolism, can activate surface adenosine
receptors. Given the association of polymorphonuclear leukocytes (PMNs) with adenine
nucleotide/nucleoside signaling in the inflammatory milieu, it was recently demonstrated that
PMNs actively release ATP via a connexin 43 hemichannel-dependent mechanism. Here …
triphosphate (ATP) liberated during hypoxia or inflammation can either signal directly to
purinergic receptors or, after phosphohydrolytic metabolism, can activate surface adenosine
receptors. Given the association of polymorphonuclear leukocytes (PMNs) with adenine
nucleotide/nucleoside signaling in the inflammatory milieu, it was recently demonstrated that
PMNs actively release ATP via a connexin 43 hemichannel-dependent mechanism. Here …