[HTML][HTML] Molecular chaperones and the assembly of the prion Ure2p in vitro
J Savistchenko, J Krzewska, N Fay, R Melki - Journal of biological chemistry, 2008 - ASBMB
The protein Ure2 from Saccharomyces cerevisiae possesses prion properties at the origin of
the [URE3] trait. In vivo, a high molecular weight form of inactive Ure2p is associated to
[URE3]. The faithful and continued propagation of [URE3] is dependent on the expression
levels of molecular chaperones from the Hsp100,-70, and-40 families; however, so far, their
role is not fully documented. Here we investigate the effects of molecular chaperones from
the Hsp40, Hsp70, Hsp90, and Hsp100 families and the chaperonin CCT/Tric on the …
the [URE3] trait. In vivo, a high molecular weight form of inactive Ure2p is associated to
[URE3]. The faithful and continued propagation of [URE3] is dependent on the expression
levels of molecular chaperones from the Hsp100,-70, and-40 families; however, so far, their
role is not fully documented. Here we investigate the effects of molecular chaperones from
the Hsp40, Hsp70, Hsp90, and Hsp100 families and the chaperonin CCT/Tric on the …