New treatment strategies in childhood acute lymphoblastic leukaemia
M Schrappe, R Beier, B Bürger - Best Practice & Research Clinical …, 2002 - Elsevier
Today, 80% of paediatric patients with acute lymphoblastic leukaemia (ALL) can be cured.
To reduce the rate of relapses, but also to limit treatment morbidity, risk-adapted treatment
has been attempted after identifying the most specific prognostic factors. In addition to
clinical factors (eg age, WBC), the immunophenotype and cytogenetic results, the early in
vivo treatment response as determined by cytology had evolved as the most important
predictor for relapse. The lack of specificity of most prognostic factors stimulated the search …
To reduce the rate of relapses, but also to limit treatment morbidity, risk-adapted treatment
has been attempted after identifying the most specific prognostic factors. In addition to
clinical factors (eg age, WBC), the immunophenotype and cytogenetic results, the early in
vivo treatment response as determined by cytology had evolved as the most important
predictor for relapse. The lack of specificity of most prognostic factors stimulated the search …