PKCtheta: A potential therapeutic target for T-cell-mediated diseases.

D Chaudhary, M Kasaian - Current Opinion in Investigational Drugs …, 2006 - europepmc.org
D Chaudhary, M Kasaian
Current Opinion in Investigational Drugs (London, England: 2000), 2006europepmc.org
Protein kinase (PK) Ctheta belongs to the calcium-independent novel subfamily of PKCs,
which itself is a member of the cAMP-dependent, cGMP-dependent PKC kinase superfamily.
As a critical regulator of T-cell receptor (TCR) signaling, PKCtheta is required for mature T-
cell activation. PKCtheta regulates helper T-cell (Th) 2-dependent pulmonary inflammation
and airway hyperresponsiveness following immunization and lung challenge with
ovalbumin in vivo, and controls Th1 cells in experimental autoimmune encephalomyelitis. Its …
Protein kinase (PK) Ctheta belongs to the calcium-independent novel subfamily of PKCs, which itself is a member of the cAMP-dependent, cGMP-dependent PKC kinase superfamily. As a critical regulator of T-cell receptor (TCR) signaling, PKCtheta is required for mature T-cell activation. PKCtheta regulates helper T-cell (Th) 2-dependent pulmonary inflammation and airway hyperresponsiveness following immunization and lung challenge with ovalbumin in vivo, and controls Th1 cells in experimental autoimmune encephalomyelitis. Its selective role in T-cell effector function and the TCR signalosome, although not in T-cell development, makes PKCtheta an attractive therapeutic target in T-cell-mediated disease processes. This review discusses the regulation and role of PKCtheta in T-cell-mediated diseases.
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