Alternative splicing within the ligand binding domain of the human constitutive androstane receptor
RS Savkur, Y Wu, KS Bramlett, M Wang, S Yao… - Molecular genetics and …, 2003 - Elsevier
The human constitutive androstane receptor (hCAR; NR1I3) is a member of the nuclear
receptor superfamily. The activity of hCAR is regulated by a variety of xenobiotics including
clotrimazole and acetaminophen metabolites. hCAR, in turn, regulates a number of genes
responsible for xenobiotic metabolism and transport including several cytochrome P450s
(CYP 2B5, 2C9, and 3A4) and the multidrug resistance-associated protein 2 (MRP2,
ABCC2). Thus, hCAR is believed to be a mediator of drug–drug interactions. We identified …
receptor superfamily. The activity of hCAR is regulated by a variety of xenobiotics including
clotrimazole and acetaminophen metabolites. hCAR, in turn, regulates a number of genes
responsible for xenobiotic metabolism and transport including several cytochrome P450s
(CYP 2B5, 2C9, and 3A4) and the multidrug resistance-associated protein 2 (MRP2,
ABCC2). Thus, hCAR is believed to be a mediator of drug–drug interactions. We identified …