Activation of complement and contact system in Alzheimer's disease
L Bergamaschini, C Donarini, G Gobbo… - Mechanisms of ageing …, 2001 - Elsevier
β-Amyloid protein (βA) has been implicated in the pathogenesis of Alzheimer's disease (AD)
because of its neurotoxicity and ability to trigger a local inflammatory response. Although
assembly of βA in particular aggregates seems to be crucial event in AD pathogenesis,
soluble, non-fibrillar βA may also be involved. Non-fibrillar βA1-42, and truncated peptide 1–
28, induced dose-dependent activation of C4 sparing C3. The mechanism of C4 activation
was not dependent on C1q, because non-fibrillar βA can still activate C4 in plasma …
because of its neurotoxicity and ability to trigger a local inflammatory response. Although
assembly of βA in particular aggregates seems to be crucial event in AD pathogenesis,
soluble, non-fibrillar βA may also be involved. Non-fibrillar βA1-42, and truncated peptide 1–
28, induced dose-dependent activation of C4 sparing C3. The mechanism of C4 activation
was not dependent on C1q, because non-fibrillar βA can still activate C4 in plasma …