[HTML][HTML] Evidence of a U‐shaped association between factor XII activity and overall survival

G Endler, C Marsik, B Jilma, T Schickbauer… - Journal of Thrombosis …, 2007 - Elsevier
Introduction: The clinical relevance of decreased coagulation factor XII (FXII) plasma activity
as a risk factor for both venous and arterial thrombosis is still discussed controversially. The
current study evaluated the predictive value of FXII levels for all‐cause mortality in a large
Viennese patient cohort. Patients and methods: Individuals, whose FXII activity levels were
determined for suspected coagulation disorders or thrombophilia screening between 1991–
2003 were included in this study (n= 8936, 51% male, 49% female, median age 43 years) …