[HTML][HTML] Glycation induces formation of amyloid cross-β structure in albumin

B Bouma, LMJ Kroon-Batenburg, YP Wu… - Journal of biological …, 2003 - ASBMB
Amyloid fibrils are components of proteinaceous plaques that are associated with
conformational diseases such as Alzheimer's disease, transmissible spongiform
encephalopathies, and familial amyloidosis. Amyloid polypeptides share a specific
quarternary structure element known as cross-β structure. Commonly, fibrillar aggregates
are modified by advanced glycation end products (AGE). In addition, AGE formation itself
induces protein aggregation. Both amyloid proteins and protein-AGE adducts bind …