Pseudomonas aeruginosa Cell-to-Cell Signaling Is Required for Virulence in a Model of Acute Pulmonary Infection
JP Pearson, M Feldman, BH Iglewski… - Infection and …, 2000 - Am Soc Microbiol
JP Pearson, M Feldman, BH Iglewski, A Prince
Infection and immunity, 2000•Am Soc MicrobiolCell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We
tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI
double mutant was nearly avirulent, and the respective single mutant strains were reduced
in virulence compared with the wild-type strain. Quorum sensing plays a role in P.
aeruginosa pneumonia in neonatal mice.
tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI
double mutant was nearly avirulent, and the respective single mutant strains were reduced
in virulence compared with the wild-type strain. Quorum sensing plays a role in P.
aeruginosa pneumonia in neonatal mice.
Abstract
Cell-to-cell signaling controls many virulence genes inPseudomonas aeruginosa. We tested the virulence oflas and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.
American Society for Microbiology