Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
TC Chou, P Talalay - Advances in enzyme regulation, 1984 - Elsevier
A generalized method for analyzing the effects of multiple drugs and for determining
summation, synergism and antagonism has been proposed. The derived, generalized
equations are based on kinetic principles. The method is relatively simple and is not limited
by 1) whether the dose-effect relationships are hyperbolic or sigmoidal, 2) whether the
effects of the drugs are mutually exclusive or nonexclusive, 3) whether the ligand
interactions are competitive, noncompetitive or uncompetitive, 4) whether the drugs are …
summation, synergism and antagonism has been proposed. The derived, generalized
equations are based on kinetic principles. The method is relatively simple and is not limited
by 1) whether the dose-effect relationships are hyperbolic or sigmoidal, 2) whether the
effects of the drugs are mutually exclusive or nonexclusive, 3) whether the ligand
interactions are competitive, noncompetitive or uncompetitive, 4) whether the drugs are …