Colchicine antimitosis causes progression of S-(1, 2-dichlorovinyl)-L-cysteine-induced injury leading to acute renal failure and death in mice

RN Reddy, JR Latendresse, HM Mehendale - Toxicology, 2006 - Elsevier
Objective of the present study was to test the importance of tissue repair in the final outcome
of S-(1, 2-dichlorovinyl)-l-cysteine (DCVC)-induced nephrotoxicity using colchicine (CLC)
intervention. Male Swiss Webster (SW) mice were administered a normally nonlethal dose of
DCVC (30mg/kg, ip) on day 0 and CLC (2mg/kg, ip) at 42 and 66h after administration of
DCVC. The mice were observed for mortality and various renal injury and repair parameters
were studied during a time course of 0–14 days. Administration of 30mg DCVC/kg led to loss …