Randomized clinical trial of single- versus multiple-dose antimicrobial prophylaxis in gastric cancer surgery
Y Mohri, H Tonouchi, M Kobayashi… - Journal of British …, 2007 - academic.oup.com
Y Mohri, H Tonouchi, M Kobayashi, K Nakai, M Kusunoki
Journal of British Surgery, 2007•academic.oup.comBackground The optimum duration of antimicrobial prophylaxis in elective gastric cancer
surgery is still open to question. This multicentre randomized clinical trial compared a single-
dose with a multiple-dose regimen of antimicrobial prophylaxis for prevention of surgical-site
infection. Methods Between May 2001 and December 2004, 501 patients undergoing
elective surgery for gastric cancer in ten centres were allocated randomly to single-or
multiple-dose antimicrobial prophylaxis. The primary outcome measure was the incidence of …
surgery is still open to question. This multicentre randomized clinical trial compared a single-
dose with a multiple-dose regimen of antimicrobial prophylaxis for prevention of surgical-site
infection. Methods Between May 2001 and December 2004, 501 patients undergoing
elective surgery for gastric cancer in ten centres were allocated randomly to single-or
multiple-dose antimicrobial prophylaxis. The primary outcome measure was the incidence of …
Background
The optimum duration of antimicrobial prophylaxis in elective gastric cancer surgery is still open to question. This multicentre randomized clinical trial compared a single-dose with a multiple-dose regimen of antimicrobial prophylaxis for prevention of surgical-site infection.
Methods
Between May 2001 and December 2004, 501 patients undergoing elective surgery for gastric cancer in ten centres were allocated randomly to single- or multiple-dose antimicrobial prophylaxis. The primary outcome measure was the incidence of surgical-site infection, analysed by intention to treat.
Results
Some 243 patients who received a single dose and 243 who received multiple doses of antibiotics were included in the final analysis. The surgical-site infection rate was 9·5 per cent (23 of 243) and 8·6 per cent (21 of 243) respectively (difference 0·9 (95 per cent confidence interval − 4·3 to 5·9) per cent). Antimicrobial prophylaxis had no major adverse effects.
Conclusion
The incidence of surgical-site infection in elective gastric cancer surgery was similar with both antibiotic prophylaxis regimens.
Oxford University Press