Implantation of colon cancer at trocar sites is increased by low pressure pneumoperitoneum
JS Wu, EB Brasfield, LW Guo, M Ruiz, JM Connett… - Surgery, 1997 - Elsevier
JS Wu, EB Brasfield, LW Guo, M Ruiz, JM Connett, GW Philpott, DB Jones, JW Fleshman
Surgery, 1997•ElsevierBackground. The purpose of this study was to determine the effect of pneumoperitoneum on
the implantation of tumor at trocar sites. Methods. GW-39 human colon cancer cell
suspension (0.5 ml of 2.5% rmv v) was injected into the peritoneal cavity of golden Syrian
hamsters through a 1 cm midline incision. Four 5 mm trocars were inserted through the
anterior abdominal wall, and the midline incision was then closed. The animals were
randomized to receive pneumoperitoneum (n= 62) or no pneumoperitoneum (n= 60) for 10 …
the implantation of tumor at trocar sites. Methods. GW-39 human colon cancer cell
suspension (0.5 ml of 2.5% rmv v) was injected into the peritoneal cavity of golden Syrian
hamsters through a 1 cm midline incision. Four 5 mm trocars were inserted through the
anterior abdominal wall, and the midline incision was then closed. The animals were
randomized to receive pneumoperitoneum (n= 62) or no pneumoperitoneum (n= 60) for 10 …
Background
The purpose of this study was to determine the effect of pneumoperitoneum on the implantation of tumor at trocar sites.
Methods
GW-39 human colon cancer cell suspension (0.5 ml of 2.5% rmv v ) was injected into the peritoneal cavity of golden Syrian hamsters through a 1 cm midline incision. Four 5 mm trocars were inserted through the anterior abdominal wall, and the midline incision was then closed. The animals were randomized to receive pneumoperitoneum (n = 62) or no pneumoperitoneum (n = 60) for 10 minutes. Tumor implantations at trocar sites and midline wound incisions were documented grossly and histologically 8 weeks later.
Results
Tumor was identified in 86% (49 of 57) of control animals and 95% (52 of 55) of the experimental group (p = 0.20). Implants increased with pneumoperitoneum at the midline incision from 44% to 71% (p < 0.01) and at trocar sites from 41% to 64% (p < 0.00001).
Conclusions
Pneumoperitoneum significantly increased tumor implantation at trocar sites and midline incisions.
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