[HTML][HTML] A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly
D Fasshauer, M Margittai - Journal of Biological Chemistry, 2004 - ASBMB
The SNARE proteins syntaxin, SNAP-25, and synaptobrevin play a central role during Ca 2+-
dependent exocytosis at the nerve terminal. Whereas syntaxin and SNAP-25 are located in
the plasma membrane, synaptobrevin resides in the membrane of synaptic vesicles. It is
thought that gradual assembly of these proteins into a membrane-bridging ternary SNARE
complex ultimately leads to membrane fusion. According to this model, syntaxin and SNAP-
25 constitute an acceptor complex for synaptobrevin. In vitro, however, syntaxin and SNAP …
dependent exocytosis at the nerve terminal. Whereas syntaxin and SNAP-25 are located in
the plasma membrane, synaptobrevin resides in the membrane of synaptic vesicles. It is
thought that gradual assembly of these proteins into a membrane-bridging ternary SNARE
complex ultimately leads to membrane fusion. According to this model, syntaxin and SNAP-
25 constitute an acceptor complex for synaptobrevin. In vitro, however, syntaxin and SNAP …