[HTML][HTML] The putative β4-adrenergic receptor is a novel state of the β1-adrenergic receptor
JG Granneman - American Journal of Physiology …, 2001 - journals.physiology.org
American Journal of Physiology-Endocrinology And Metabolism, 2001•journals.physiology.org
The atypical β 3-adrenergic receptor (AR) agonist CGP-12177 has been used to define a
novel atypical β-AR subtype, the putative β 4-AR. Recent evaluation of recombinant β-AR
subtypes and β-AR-deficient mice, however, has established the identity of the
pharmacological β 4-AR as a novel state of the β 1-AR protein. The ability of
aryloxypropanolamine ligands like CGP-12177 to independently interact with agonist and
antagonist states of the β 1-AR has important implications regarding receptor classification …
novel atypical β-AR subtype, the putative β 4-AR. Recent evaluation of recombinant β-AR
subtypes and β-AR-deficient mice, however, has established the identity of the
pharmacological β 4-AR as a novel state of the β 1-AR protein. The ability of
aryloxypropanolamine ligands like CGP-12177 to independently interact with agonist and
antagonist states of the β 1-AR has important implications regarding receptor classification …
Abstract
The atypical β 3-adrenergic receptor (AR) agonist CGP-12177 has been used to define a novel atypical β-AR subtype, the putative β 4-AR. Recent evaluation of recombinant β-AR subtypes and β-AR-deficient mice, however, has established the identity of the pharmacological β 4-AR as a novel state of the β 1-AR protein. The ability of aryloxypropanolamine ligands like CGP-12177 to independently interact with agonist and antagonist states of the β 1-AR has important implications regarding receptor classification and the potential development of tissue-specific β-AR agonists.
American Physiological Society