[HTML][HTML] Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated …

JY Lee, J Ye, Z Gao, HS Youn, WH Lee, L Zhao… - Journal of Biological …, 2003 - ASBMB
Toll-like receptor-4 (TLR4) can be activated by nonbacterial agonists, including saturated
fatty acids. However, downstream signaling pathways activated by nonbacterial agonists are
not known. Thus, we determined the downstream signaling pathways derived from saturated
fatty acid-induced TLR4 activation. Saturated fatty acid (lauric acid)-induced NFκB activation
was inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6, or IκBα in
macrophages (RAW264. 7) and 293T cells transfected with TLR4 and MD2. Lauric acid …