There is now a consensus that mitochondria take up and accumulate Ca2+ during
physiological [Ca2+] csignalling. This contribution will consider some of the functional
consequences of mitochondrial Ca2+ uptake for cell physiology and pathophysiology. The
ability to remove Ca2+ from local cytosol enables mitochondria to regulate the [Ca2+] in
microdomains close to IP3-sensitive Ca2+-release channels. The [Ca2+] sensitivity of these
channels means that, by regulating local [Ca2+] c, mitochondrial Ca2+ uptake modulates the …