[HTML][HTML] Sur1 knockout mice: a model for KATP channel-independent regulation of insulin secretion
V Seghers, M Nakazaki, F DeMayo… - Journal of Biological …, 2000 - ASBMB
Sur1 knockout mouse β-cells lack K ATP channels and show spontaneous Ca 2+ action
potentials equivalent to those seen in patients with persistent hyperinsulinemic
hypoglycemia of infancy, but the mice are normoglycemic unless stressed. Sur1–/–islets lack
first phase insulin secretion and exhibit an attenuated glucose-stimulated second phase
secretion. Loss of the first phase leads to mild glucose intolerance, whereas reduced insulin
output is consistent with observed neonatal hyperglycemia. Loss of K ATP channels impairs …
potentials equivalent to those seen in patients with persistent hyperinsulinemic
hypoglycemia of infancy, but the mice are normoglycemic unless stressed. Sur1–/–islets lack
first phase insulin secretion and exhibit an attenuated glucose-stimulated second phase
secretion. Loss of the first phase leads to mild glucose intolerance, whereas reduced insulin
output is consistent with observed neonatal hyperglycemia. Loss of K ATP channels impairs …