[HTML][HTML] A signaling role of glutamine in insulin secretion
C Li, C Buettger, J Kwagh, A Matter, Y Daikhin… - Journal of Biological …, 2004 - ASBMB
Children with hypoglycemia due to recessive loss of function mutations of the β-cell ATP-
sensitive potassium (K ATP) channel can develop hypoglycemia in response to protein
feeding. We hypothesized that amino acids might stimulate insulin secretion by unknown
mechanisms, because the K ATP channel-dependent pathway of insulin secretion is
defective. We therefore investigated the effects of amino acids on insulin secretion and
intracellular calcium in islets from normal and sulfonylurea receptor 1 knockout (SUR1–/–) …
sensitive potassium (K ATP) channel can develop hypoglycemia in response to protein
feeding. We hypothesized that amino acids might stimulate insulin secretion by unknown
mechanisms, because the K ATP channel-dependent pathway of insulin secretion is
defective. We therefore investigated the effects of amino acids on insulin secretion and
intracellular calcium in islets from normal and sulfonylurea receptor 1 knockout (SUR1–/–) …