Accuracy of [18F]Fluorodopa Positron Emission Tomography for Diagnosing and Localizing Focal Congenital Hyperinsulinism
OT Hardy, M Hernandez-Pampaloni… - The Journal of …, 2007 - academic.oup.com
OT Hardy, M Hernandez-Pampaloni, JR Saffer, JS Scheuermann, LM Ernst, R Freifelder…
The Journal of Clinical Endocrinology & Metabolism, 2007•academic.oup.comObjectives: Focal lesions in infants with congenital hyperinsulinism (HI) represent areas of
adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation
due to embryonic loss of heterozygosity for the maternal 11p region. This study evaluated
the accuracy of 18F-fluoro-l-dihydroxyphenylalanine ([18F] DOPA) positron emission
tomography (PET) scans in diagnosing focal vs. diffuse disease and identifying the location
of focal lesions. Design: A total of 50 infants with HI unresponsive to medical therapy were …
adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation
due to embryonic loss of heterozygosity for the maternal 11p region. This study evaluated
the accuracy of 18F-fluoro-l-dihydroxyphenylalanine ([18F] DOPA) positron emission
tomography (PET) scans in diagnosing focal vs. diffuse disease and identifying the location
of focal lesions. Design: A total of 50 infants with HI unresponsive to medical therapy were …
Abstract
Objectives: Focal lesions in infants with congenital hyperinsulinism (HI) represent areas of adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation due to embryonic loss of heterozygosity for the maternal 11p region. This study evaluated the accuracy of 18F-fluoro-l-dihydroxyphenylalanine ([18F]DOPA) positron emission tomography (PET) scans in diagnosing focal vs. diffuse disease and identifying the location of focal lesions.
Design: A total of 50 infants with HI unresponsive to medical therapy were studied. Patients were injected iv with [18F]DOPA, and PET scans were obtained for 50–60 min. Images were coregistered with abdominal computed tomography scans. PET scan interpretations were compared with histological diagnoses.
Results: The diagnosis of focal or diffuse HI was correct in 44 of the 50 cases (88%). [18F]DOPA PET identified focal areas of high uptake of radiopharmaceutical in 18 of 24 patients with focal disease. The locations of these lesions matched the areas of increased [18F]DOPA uptake on the PET scans in all of the cases. PET scan correctly located five lesions that could not be visualized at surgery. The positive predictive value of [18F]DOPA in diagnosing focal adenomatosis was 100%, and the negative predictive value was 81%.
Conclusions: [18F]DOPA PET scans correctly diagnosed 75% of focal cases and were 100% accurate in identifying the location of the lesion. These results suggest that [18F]DOPA PET imaging provides a useful guide to surgical resection of focal adenomatosis and should be considered as a guide to surgery in all infants with congenital HI who have medically uncontrollable disease.
Oxford University Press