[HTML][HTML] UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells
F Ocklenburg, D Moharregh-Khiabani, R Geffers… - Laboratory …, 2006 - Elsevier
Here, we report the identification of the ubiquitin-like gene UBD as a downstream element of
FOXP3 in human activated regulatory CD4+ CD25 hi T cells (T reg). Retroviral transduction
of UBD in human allo-reactive effector CD4+ T helper (T h) cells upregulates CD25 and
mediates downregulation of IL4 and IL5 expression similar to overexpression of FOXP3.
Moreover, UBD impairs T h cell proliferation without upregulation of FOXP3 and impairs
calcium mobilization. In the presence of ionomycin, overexpression of UBD in T h cells leads …
FOXP3 in human activated regulatory CD4+ CD25 hi T cells (T reg). Retroviral transduction
of UBD in human allo-reactive effector CD4+ T helper (T h) cells upregulates CD25 and
mediates downregulation of IL4 and IL5 expression similar to overexpression of FOXP3.
Moreover, UBD impairs T h cell proliferation without upregulation of FOXP3 and impairs
calcium mobilization. In the presence of ionomycin, overexpression of UBD in T h cells leads …