[HTML][HTML] Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf
Newly synthesized thyroglobulin (Tg), the secretory glycoprotein that serves as precursor in
thyroid hormone synthesis, normally forms transient covalent protein complexes with
oxidoreductases of the endoplasmic reticulum (ER). The Tg-G2320R mutation is responsible
for congenital hypothyroidism in rdw/rdw rats, in which a lack of secondary thyroid
enlargement (goiter) implicates death of thyrocytes as part of disease pathogenesis. We
found that mutant Tg-G2320R was retained within the ER with no detectable synthesis of …
thyroid hormone synthesis, normally forms transient covalent protein complexes with
oxidoreductases of the endoplasmic reticulum (ER). The Tg-G2320R mutation is responsible
for congenital hypothyroidism in rdw/rdw rats, in which a lack of secondary thyroid
enlargement (goiter) implicates death of thyrocytes as part of disease pathogenesis. We
found that mutant Tg-G2320R was retained within the ER with no detectable synthesis of …