The generation of the enzyme thrombin from its precursor prothrombin is the central event of
the blood coagulation process, which is essential to hemostasis and the culprit in
thrombosis. Thrombin is produced by a complex series of proteolytic events that are initiated
when cryptic tissue factor interacts with plasma factor VIIa to initiate the complex series of
events leading to the formation of the blood coagulation enzyme complexes that lead to the
efficient generation of the enzyme. During these processes, thrombin contributes to both the …