[HTML][HTML] STAT5b-deficient mice are growth hormone pulse-resistant: role of STAT5b in sex-specific liver P450 expression
HW Davey, SH Park, DR Grattan, MJ McLachlan… - Journal of Biological …, 1999 - ASBMB
The signal transducer and transcriptional activator STAT5b is required to maintain the adult
male pattern of liver gene expression and whole body pubertal growth rates, as
demonstrated by the loss of these growth hormone (GH) pulse-dependent responses in
mice with a targeted disruption of the STAT5b gene. The present study investigates whether
these phenotypes of STAT5b-deficient mice result from impaired intracellular GH signaling
associated with a loss of GH pulse responsiveness, as contrasted with a feminization of the …
male pattern of liver gene expression and whole body pubertal growth rates, as
demonstrated by the loss of these growth hormone (GH) pulse-dependent responses in
mice with a targeted disruption of the STAT5b gene. The present study investigates whether
these phenotypes of STAT5b-deficient mice result from impaired intracellular GH signaling
associated with a loss of GH pulse responsiveness, as contrasted with a feminization of the …