Receptor-associated resistance to growth hormone-releasing factor in dwarf" little" mice
JO Jansson, TR Downs, WG Beamer, LA Frohman - Science, 1986 - science.org
JO Jansson, TR Downs, WG Beamer, LA Frohman
Science, 1986•science.orgAnterior pituitaries from the dwarf mouse strain" little" did not release growth hormone or
accumulate adenosine 3′, 5′-monophosphate (cyclic AMP) in response to human and rat
growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate
cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH)
release. The basis of the GH deficiency in the little mouse may therefore be a defect in an
early stage of GRF-stimulated GH release related either to receptor binding or to the function …
accumulate adenosine 3′, 5′-monophosphate (cyclic AMP) in response to human and rat
growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate
cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH)
release. The basis of the GH deficiency in the little mouse may therefore be a defect in an
early stage of GRF-stimulated GH release related either to receptor binding or to the function …
Anterior pituitaries from the dwarf mouse strain "little" did not release growth hormone or accumulate adenosine 3′,5′-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH) release. The basis of the GH deficiency in the little mouse may therefore be a defect in an early stage of GRF-stimulated GH release related either to receptor binding or to the function of the hormone-receptor complex.
AAAS