Alloimmune thrombocytopenia: state of the art 2006
RL Berkowitz, JB Bussel, JG McFarland - American journal of obstetrics and …, 2006 - Elsevier
In alloimmune thrombocytopenia maternal immunoglobulin G anti-platelet alloantibodies
cross the placenta and cause fetal thrombocytopenia. The diagnosis requires laboratory
demonstration of incompatibility between a maternal and paternal platelet alloantigen, and
detection of maternal antibody to the discordant paternal alloantigen. This disorder should
be treated in utero because of its propensity to cause fetal intracranial bleeding.
Administration of intravenous immunoglobulin 1 gm/kg/wk to the mother is successful in …
cross the placenta and cause fetal thrombocytopenia. The diagnosis requires laboratory
demonstration of incompatibility between a maternal and paternal platelet alloantigen, and
detection of maternal antibody to the discordant paternal alloantigen. This disorder should
be treated in utero because of its propensity to cause fetal intracranial bleeding.
Administration of intravenous immunoglobulin 1 gm/kg/wk to the mother is successful in …