[HTML][HTML] hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
MP Byfield, JT Murray, JM Backer - Journal of Biological Chemistry, 2005 - ASBMB
Mammalian cells respond to nutrient deprivation by inhibiting energy consuming processes,
such as proliferation and protein synthesis, and by stimulating catabolic processes, such as
autophagy. p70 S6 kinase (S6K1) plays a central role during nutritional regulation of
translation. S6K1 is activated by growth factors such as insulin, and by mammalian target of
rapamycin (mTOR), which is itself regulated by amino acids. The Class IA
phosphatidylinositol (PI) 3-kinase plays a well recognized role in the regulation of S6K1. We …
such as proliferation and protein synthesis, and by stimulating catabolic processes, such as
autophagy. p70 S6 kinase (S6K1) plays a central role during nutritional regulation of
translation. S6K1 is activated by growth factors such as insulin, and by mammalian target of
rapamycin (mTOR), which is itself regulated by amino acids. The Class IA
phosphatidylinositol (PI) 3-kinase plays a well recognized role in the regulation of S6K1. We …