[HTML][HTML] β-amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons
BL Kelly, A Ferreira - Journal of Biological Chemistry, 2006 - ASBMB
Alzheimer disease (AD) is a progressive, neurodegenerative disorder that leads to
debilitating cognitive deficits. Although little is known about the early functional or
ultrastructural changes associated with AD, it has been proposed that a stage of synaptic
dysfunction might precede neurodegeneration in the development of this disease.
Unfortunately, the molecular mechanisms that underlie such synaptic dysfunction remain
largely unknown. Recently we have shown that β-amyloid (Aβ), the main component of …
debilitating cognitive deficits. Although little is known about the early functional or
ultrastructural changes associated with AD, it has been proposed that a stage of synaptic
dysfunction might precede neurodegeneration in the development of this disease.
Unfortunately, the molecular mechanisms that underlie such synaptic dysfunction remain
largely unknown. Recently we have shown that β-amyloid (Aβ), the main component of …