[HTML][HTML] Smad4 protein stability is regulated by ubiquitin ligase SCFβ-TrCP1
M Wan, Y Tang, EM Tytler, C Lu, B Jin… - Journal of Biological …, 2004 - ASBMB
Smad4 is a key intracellular mediator for the transforming growth factor-β (TGF-β)
superfamily of growth factors and is also an important tumor suppressor. The receptor-
regulated Smad (R-Smad) proteins are regulated by ubiquitin-mediated degradation, yet the
precise control of Smad4 protein stability is unclear. We have identified SCF β-TrCP1, a
ubiquitin (E3) ligase, as a critical determinant for the protein degradation of Smad4 protein. F-
box protein β-TrCP1 in this E3 ligase interacts with Smad4 both in yeast and in mammalian …
superfamily of growth factors and is also an important tumor suppressor. The receptor-
regulated Smad (R-Smad) proteins are regulated by ubiquitin-mediated degradation, yet the
precise control of Smad4 protein stability is unclear. We have identified SCF β-TrCP1, a
ubiquitin (E3) ligase, as a critical determinant for the protein degradation of Smad4 protein. F-
box protein β-TrCP1 in this E3 ligase interacts with Smad4 both in yeast and in mammalian …