[HTML][HTML] The logic of TGFβ signaling

J Massagué, RR Gomis - FEBS letters, 2006 - Elsevier
FEBS letters, 2006Elsevier
The identification of the TGFβ cytokine signaling pathway, including membrane receptor
serine/threonine kinases and Smad transcription factors as their substrates, has allowed the
delineation of a process for conversion of these signals into programs of gene activation and
repression that underlie critical cell fate and developmental decisions. The deconstruction of
one of these responses–the cell cycle arrest response–into its elemental molecular parts
has shed light into the mechanisms used by tumors to evade surveillance and cause …
The identification of the TGFβ cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses – the cell cycle arrest response – into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.
Elsevier