Atherosclerosis is now widely recognized as a chronic inflammatory disease that involves
innate and adaptive immune responses. Both cellular and humoral components of the
immune system have been implicated in atherogenesis. Natural antibodies can be
considered humoral factors of innate immunity, and their functional role in health and
disease has been reexamined in recent years. Natural antibodies exhibit a remarkably
conserved repertoire that includes a broad specificity for self-antigens. For this reason, they …