Tachyphylaxis to the effects of anorexigenic agents, such as sibutramine (S), may be due, in
part, to counterregulatory decreases in energy expenditure (EE) and increases in hunger
that result from reduced circulating leptin (L) due to loss of body fat and lowered L
production/adipocyte. The present study was conducted to test the hypothesis that L
administered at low doses sufficient to restore ambient L to preweight loss concentrations
would enhance the intercurrent efficacy of S by reducing the strength of physiologic …