[HTML][HTML] Distinct kinetics for binding of the CD46 and SLAM receptors to overlapping sites in the measles virus hemagglutinin protein
C Santiago, E Björling, T Stehle… - Journal of Biological …, 2002 - ASBMB
Measles virus (MV) is a human pathogen using two distinct cell surface receptors for entry
into host cells. We present here a comparative analysis for binding of the MV receptors
CD46 and SLAM to the measles virus hemagglutinin protein (MVH, Edmonston strain).
Soluble monomeric and dimeric MVH variants were prepared in mammalian cells and their
conformation assessed using a panel of monoclonal antibodies. The two receptor molecules
specifically bound to the MVH protein with distinct binding modes. The association rate (ka) …
into host cells. We present here a comparative analysis for binding of the MV receptors
CD46 and SLAM to the measles virus hemagglutinin protein (MVH, Edmonston strain).
Soluble monomeric and dimeric MVH variants were prepared in mammalian cells and their
conformation assessed using a panel of monoclonal antibodies. The two receptor molecules
specifically bound to the MVH protein with distinct binding modes. The association rate (ka) …