Several lines of evidence indicate a role for the tachykinin peptides in airways diseases. For
instance, elevated levels of tachykinins have been recovered from the airways of patients
with asthma and chronic obstructive pulmonary disease (COPD), and airway inflammation
leads to an upregulation of the tachykinin NK1 and NK2 receptors. Recent advances in
tachykinin receptor pharmacology have allowed a more detailed analysis of this system and
preclinical animal studies have indicated a role for the NK1 and NK2 receptors in …