Stable prodrugs of n-butyric acid: suppression of T cell alloresponses in vitro and prolongation of heart allograft survival in a fully allogeneic rat strain combination
GA Böhmig, PM Krieger, MD Säemann, R Ullrich… - Transplant …, 1999 - Elsevier
n-Butyric acid has previously been shown in vitro to suppress T cell alloresponses and
beyond that to induce a state of alloantigen-specific hyporesponsiveness suggesting a
potential relevance for suppressing alloresponses also in vivo. The clinical use of butyrate
salt derivatives, however, is limited by an extremely short half-life due to rapid metabolism.
This prompted us to investigate the effect of butyric acid derivatives with prolonged
residence time in vivo on T cell alloresponses in vitro and further to explore the immuno …
beyond that to induce a state of alloantigen-specific hyporesponsiveness suggesting a
potential relevance for suppressing alloresponses also in vivo. The clinical use of butyrate
salt derivatives, however, is limited by an extremely short half-life due to rapid metabolism.
This prompted us to investigate the effect of butyric acid derivatives with prolonged
residence time in vivo on T cell alloresponses in vitro and further to explore the immuno …