[HTML][HTML] Differential regulation of glycogen synthase kinase 3β by insulin and Wnt signaling
VW Ding, RH Chen, F McCormick - Journal of Biological Chemistry, 2000 - ASBMB
Glycogen synthase kinase 3β (GSK3β) is a key component in many biological processes
including insulin and Wnt signaling. Since the activation of each signaling pathway results in
a decrease in GSK3β activity, we examined the specificity of their downstream effects in the
same cell type. Insulin induces an increased activity of glycogen synthase but has no
influence on the protein level of β-catenin. In contrast, Wnt increases the cytosolic pool of β-
catenin but not glycogen synthase activity. We found that, unlike insulin, neither the …
including insulin and Wnt signaling. Since the activation of each signaling pathway results in
a decrease in GSK3β activity, we examined the specificity of their downstream effects in the
same cell type. Insulin induces an increased activity of glycogen synthase but has no
influence on the protein level of β-catenin. In contrast, Wnt increases the cytosolic pool of β-
catenin but not glycogen synthase activity. We found that, unlike insulin, neither the …