Endogenous nociceptin signaling and stress-induced analgesia
A Rizzi, G Marzola, R Bigoni, R Guerrini, S Salvadori… - …, 2001 - journals.lww.com
Nociceptin/orphanin FQ (NC) and its receptor (OP 4) have been implicated in pain
transmission. The aim of the present study was to investigate the role of the NC/OP 4 system
in stress-induced analgesia (SIA). The tail-withdrawal assay was performed in mice stressed
by forced swimming in water at 15 C (high severity swims) or 32 C (low severity swims). High
severity swims produced a naloxone-insensitive antinociceptive effect which was blocked by
supraspinal NC (1 nmol). The selective OP 4 receptor antagonist,[Nphe 1] NC (-13) NH 2 (30 …
transmission. The aim of the present study was to investigate the role of the NC/OP 4 system
in stress-induced analgesia (SIA). The tail-withdrawal assay was performed in mice stressed
by forced swimming in water at 15 C (high severity swims) or 32 C (low severity swims). High
severity swims produced a naloxone-insensitive antinociceptive effect which was blocked by
supraspinal NC (1 nmol). The selective OP 4 receptor antagonist,[Nphe 1] NC (-13) NH 2 (30 …