[HTML][HTML] Hijacking of the Human Alkyl-N-purine-DNA Glycosylase by 3, N4-Ethenocytosine, a Lipid Peroxidation-induced DNA Adduct*[boxs]
L Gros, AV Maksimenko, CV Privezentzev… - Journal of Biological …, 2004 - ASBMB
Lipid peroxidation generates aldehydes, which react with DNA bases, forming genotoxic
exocyclic etheno (ϵ)-adducts. E-bases have been implicated in vinyl chloride-induced
carcinogenesis, and increased levels of these DNA lesions formed by endogenous
processes are found in human degenerative disorders. E-adducts are repaired by the base
excision repair pathway. Here, we report the efficient biological hijacking of the human alkyl-
N-purine-DNA glycosylase (ANPG) by 3, N 4-ethenocytosine (ϵC) when present in DNA …
exocyclic etheno (ϵ)-adducts. E-bases have been implicated in vinyl chloride-induced
carcinogenesis, and increased levels of these DNA lesions formed by endogenous
processes are found in human degenerative disorders. E-adducts are repaired by the base
excision repair pathway. Here, we report the efficient biological hijacking of the human alkyl-
N-purine-DNA glycosylase (ANPG) by 3, N 4-ethenocytosine (ϵC) when present in DNA …